Society for Actinomycetes Japan The
Society for
Actinomycetes
Japan



Established in 1955 and recognized in 1985 by the Science Council of Japan.
[Japanese Page]
[GIM2016] 13th International Symposium on the Genetics of Industrial Microorganisms
Wuhan, P. R. China during 16-20 October 2016
[ISBA18] 18th International Symposium on the Biology of Actinomycetes
Jeju island, Korea during 23-27 May 2017
Early Bird Registration: Jul. 1st - Dec. 31st, 2016
Professor Satoshi Omura, an honorary member of the SAJ, was awarded
the 2015 Nobel Prize in Physiology or Medicine.
2016 Annual Meeting of SAJ (Sep. 8-9, Tokyo)

Outline of SAJ

Newsletter[Up]
(Actinomycetologica)

Official Journal

JA Free Access (members only)

Digital Atlas of Actinomycetes Ver. 2 [Up]

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URL for this page is:
http://www.actino.jp/.
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Topics
[2016/06/17] The ISBA18 webpage is now live on the internet.
[2016/05/25] [GIM2016] Abstruct submission: 1 June 2016
[2015/12/25] Official newsletter Actinomycetologica Vol.29 No.2 is out.
[2015/10/7] Professor Satoshi Omura, an honorary member of the SAJ, was awarded the 2015 Nobel Prize in Physiology or Medicine.
Natural Product Discovery & Development in The Post Genomic Era (San Diego, Jan. 11-14, 2015)
ISBA'17 (Kusadasi, Turkey, Oct. 8-12, 2014)
ESF-EMBO symposium on the Synthetic Biology of Antibiotic Production II (Spain, 8/30-9/4 2014)
JA's AOP web feed

Antibiotics in the clinical pipeline at the end of 2015 June 29 2016. doi:10.1038/ja.2016.72 Mark S Butler, Mark AT Blaskovich & Matthew A Cooper

In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline June 29 2016. doi:10.1038/ja.2016.73 Yunliang Zhang, Xiaoyan Lin & Karen Bush

Antibacterial fatty acids destabilize hydrophobic and multicellular aggregates of biofilm in S. aureus June 29 2016. doi:10.1038/ja.2016.76 Zulfiqar Ali Mirani, Shagufta Naz, Fouzia Khan, Mubashir Aziz, Asadullah, Muhammad Naseem Khan & Seema Ismat Khan

Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil June 29 2016. doi:10.1038/ja.2016.78 Dominik Wichner, Hamidah Idris, Wael E Houssen, Andrew R McEwan, Alan T Bull, Juan A Asenjo, Michael Goodfellow, Marcel Jaspars, Rainer Ebel & Mostafa E Rateb

Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens June 29 2016. doi:10.1038/ja.2016.79 Hyun Bong Park & Jason M Crawford

Synthesis and biological evaluation of lipophilic teicoplanin pseudoaglycon derivatives containing a substituted triazole function June 29 2016. doi:10.1038/ja.2016.80 Zsolt Szűcs, Magdolna Csávás, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Florent Perret, Eszter Ostorházi, Réka Szatmári, Evelien Vanderlinden, Lieve Naesens & Pál Herczegh

Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1 June 22 2016. doi:10.1038/ja.2016.60 Sifan Wu, Tingting Huang, Dan Xie, Jing Wo, Xiaozheng Wang, Zixin Deng & Shuangjun Lin

Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation June 22 2016. doi:10.1038/ja.2016.61 Yuki Hirota-Takahata, Shiho Kozuma, Nahoki Kuraya, Daisuke Fukuda, Mutsuo Nakajima, Toshio Takatsu & Osamu Ando

Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants June 22 2016. doi:10.1038/ja.2016.68 Hyun Jo Koo, Christopher R Vickery, Yi Xu, Gordon V Louie, Paul E O'Maille, Marianne Bowman, Charisse M Nartey, Michael D Burkart & Joseph P Noel

Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphaeria sp. TR-022 June 22 2016. doi:10.1038/ja.2016.70 Takuya Suga, Mayu Shiina, Yukihiro Asami, Masato Iwatsuki, Tsuyoshi Yamamoto, Kenichi Nonaka, Rokuro Masuma, Hidehito Matsui, Hideaki Hanaki, Susumu Iwamoto, Hideyuki Onodera, Kazuro Shiomi & Satoshi Ōmura

Haenamindole and fumiquinazoline analogs from a fungicolous isolate of Penicillium lanosum June 22 2016. doi:10.1038/ja.2016.74 In Hyun Hwang, Yongsheng Che, Dale C Swenson, James B Gloer, Donald T Wicklow, Stephen W Peterson & Patrick F Dowd

Metacycloprodigiosin induced cell death selectively in β-catenin-mutated tumor cells June 22 2016. doi:10.1038/ja.2016.75 Hiroaki Ikeda, Yuki Shikata, Ramida Watanapokasin, Etsu Tashiro & Masaya Imoto

Surfactin derivatives from Micromonospora sp. CPCC 202787 and their anti-HIV activities June 15 2016. doi:10.1038/ja.2016.63 Xu Pang, Jianyuan Zhao, Xiaomei Fang, Hongyu Liu, Yuqin Zhang, Shan Cen & Liyan Yu

Methyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates June 15 2016. doi:10.1038/ja.2016.66 D Cole Stevens, Drew T Wagner, Hannah R Manion, Bradley K Alexander & Adrian T Keatinge-Clay

Recent advances of Diels–Alderases involved in natural product biosynthesis June 15 2016. doi:10.1038/ja.2016.67 Atsushi Minami & Hideaki Oikawa

The unique chemistry and biology of the piericidins June 15 2016. doi:10.1038/ja.2016.71 Xuefeng Zhou & William Fenical

Chemical and biological studies of reveromycin A June 8 2016. doi:10.1038/ja.2016.57 Hiroyuki Osada

Impact of Staphylococcus aureus accessory gene regulator (agr) system on linezolid efficacy by profiling pharmacodynamics and RNAIII expression June 8 2016. doi:10.1038/ja.2016.59 Rachel L Soon, Justin R Lenhard, Irene Reilly, Tanya Brown, Alan Forrest & Brian T Tsuji

RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441 June 8 2016. doi:10.1038/ja.2016.65 Jun-Pil Jang, Shunji Takahashi, Yushi Futamura, Toshihiko Nogawa, Jae-Hyuk Jang, Jong Seog Ahn & Hiroyuki Osada

Eighth Korea–Japan Chemical Biology symposium: chemical biology notes from a small island June 1 2016. doi:10.1038/ja.2016.58 Tilman Schneider-Poetsch, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn & Hiroyuki Osada

Insights into polyketide biosynthesis gained from repurposing antibiotic-producing polyketide synthases to produce fuels and chemicals June 1 2016. doi:10.1038/ja.2016.64 Satoshi Yuzawa, Jay D Keasling & Leonard Katz

Isolation and structural determination of a new antibacterial compound demethyl-L-681,217 from Streptomyces cattleya May 25 2016. doi:10.1038/ja.2016.53 Shogo Sugai, Hisayuki Komaki, Hikaru Hemmi & Shinya Kodani

Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975 May 25 2016. doi:10.1038/ja.2016.56 Hossam M Hassan, Chollaratt Boonlarppradab & William Fenical

Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus May 25 2016. doi:10.1038/ja.2016.62 Joao C S Cruz, Sonia I Maffioli, Alice Bernasconi, Cristina Brunati, Eleonora Gaspari, Margherita Sosio, Elizabeth Wellington & Stefano Donadio

Efficacy of ampicillin against methicillin-resistant Staphylococcus aureus restored through synergy with branched poly(ethylenimine) May 18 2016. doi:10.1038/ja.2016.44 Melissa A Foxley, Anthony W Friedline, Jessica M Jensen, Susan L Nimmo, Erin M Scull, Jarrod B King, Stoffel Strange, Min T Xiao, Benjamin E Smith, Kieth J Thomas III, Daniel T Glatzhofer, Robert H Cichewicz & Charles V Rice

Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis May 18 2016. doi:10.1038/ja.2016.45 Shasha Rao, Clive A Prestidge, Lynn Miesel, Deb Sweeney, Dean L Shinabarger & Ramiz A Boulos

Antibacterial activity of the novel semisynthetic lantibiotic NVB333 in vitro and in experimental infection models May 18 2016. doi:10.1038/ja.2016.47 Steven Boakes, William J Weiss, Mary Vinson, Sjoerd Wadman & Michael J Dawson

Quinovosamycins: new tunicamycin-type antibiotics in which the α, β-1″,11′-linked N-acetylglucosamine residue is replaced by N-acetylquinovosamine May 18 2016. doi:10.1038/ja.2016.49 Neil PJ Price, David P Labeda, Todd A Naumann, Karl E Vermillion, Michael J Bowman, Mark A Berhow, William W Metcalf & Kenneth M Bischoff

Using quantum chemical computations of NMR chemical shifts to assign relative configurations of terpenes from an engineered Streptomyces host May 18 2016. doi:10.1038/ja.2016.51 Q Nhu N Nguyen & Dean J Tantillo

Design, synthesis and microbiological evaluation of ampicillin–tetramic acid hybrid antibiotics May 18 2016. doi:10.1038/ja.2016.52 Philip T Cherian, Aditi Deshpande, Martin N Cheramie, David F Bruhn, Julian G Hurdle & Richard E Lee

New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145 May 18 2016. doi:10.1038/ja.2016.54 Hiroki Kato, Yuta Tsunematsu, Tsuyoshi Yamamoto, Takuya Namiki, Shinji Kishimoto, Hiroshi Noguchi & Kenji Watanabe

DNA sequence-selective C8-linked pyrrolobenzodiazepine–heterocyclic polyamide conjugates show anti-tubercular-specific activities May 11 2016. doi:10.1038/ja.2016.43 Federico Brucoli, Juan D Guzman, Mohammad A Basher, Dimitrios Evangelopoulos, Eleanor McMahon, Tulika Munshi, Timothy D McHugh, Keith R Fox & Sanjib Bhakta

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209 May 11 2016. doi:10.1038/ja.2016.46 Aika Suzuki, Takashi Fukuda, Keisuke Kobayashi, Taichi Ohshiro & Hiroshi Tomoda

Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation May 11 2016. doi:10.1038/ja.2016.48 Aysegul Saral, David A Leonard, Azer Ozad Duzgun, Aysegul Copur Cicek, Cynthia M June & Cemal Sandalli

Quantitative measurement of the outer membrane permeability in Escherichia coli lpp and tol–pal mutants defines the significance of Tol–Pal function for maintaining drug resistance May 11 2016. doi:10.1038/ja.2016.50 Hikaru Kowata, Saeko Tochigi, Tomonobu Kusano & Seiji Kojima

Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases April 27 2016. doi:10.1038/ja.2016.41 Matthew P Ostrowski, David E Cane & Chaitan Khosla

Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives April 27 2016. doi:10.1038/ja.2016.42 Zhonghui Zheng, Deping Du, Lili Cao, Jun Liu & Xiaofang Chen

General base-general acid catalysis by terpenoid cyclases April 13 2016. doi:10.1038/ja.2016.39 Travis A Pemberton & David W Christianson

Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase April 13 2016. doi:10.1038/ja.2016.40 Fumitaka Kudo, Yasunori Matsuura, Takaaki Hayashi, Masayuki Fukushima & Tadashi Eguchi

Frog skin cultures secrete anti-yellow fever compounds April 6 2016. doi:10.1038/ja.2016.16 Carolina Muñoz-Camargo, Margarita Correa Méndez, Vivian Salazar, Johanna Moscoso, Diana Narváez, Maria Mercedes Torres, Franz Kaston Florez, Helena Groot & Eduardo Mitrani

Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules April 6 2016. doi:10.1038/ja.2016.35 Junji Inokoshi, Yuichiro Nakamura, Saori Komada, Katsuichiro Komatsu, Hideaki Umeyama & Hiroshi Tomoda

Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306 March 30 2016. doi:10.1038/ja.2016.28 Tōru Kimura, Masato Iwatsuki, Yukihiro Asami, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Atsuko Matsumoto, Noriko Sato, Kazuro Shiomi, Yōko Takahashi, Satoshi Ōmura & Takuji Nakashima

Anti-Helicobacter pylori activity of some newly synthesized derivatives of xanthone March 30 2016. doi:10.1038/ja.2016.36 Karolina Klesiewicz, Elżbieta Karczewska, Alicja Budak, Henryk Marona & Natalia Szkaradek

MIC score, a new tool to compare bacterial susceptibility to antibiotics application to the comparison of susceptibility to different penems of clinical strains of Pseudomonas aeruginosa March 30 2016. doi:10.1038/ja.2016.38 Cédric Bretonnière, Adeline Maitte, Jocelyne Caillon, Gilles Potel, David Boutoille, Cédric Jacqueline & Christophe Guitton

Design and synthesis of 15-deoxyspergualin–biotin conjugates as novel binding probes for target protein screening March 23 2016. doi:10.1038/ja.2016.32 Masahiko Morioka, Kuniki Kato & Kazuo Umezawa

New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties March 23 2016. doi:10.1038/ja.2016.34 Anna N Tevyashova, Alexander M Korolev, Aleksey S Trenin, Lyubov G Dezhenkova, Alexander A Shtil, Vladimir I Polshakov, Oleg Yu Savelyev & Evgenia N Olsufyeva

7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007 March 16 2016. doi:10.1038/ja.2016.27 Ryuji Uchida, Kento Nakajyo, Keisuke Kobayashi, Taichi Ohshiro, Takeshi Terahara, Chiaki Imada & Hiroshi Tomoda

Studies on novel HIF activators, A-503451s.I. Producing organism, fermentation, isolation and structural elucidation March 9 2016. doi:10.1038/ja.2016.17 Yuki Hirota-Takahata, Hideki Kobayashi, Masaaki Kizuka, Takao Ohyama, Michiko Kitamura-Miyazaki, Yasuhiro Suzuki, Mie Fujiwara, Mutsuo Nakajima & Osamu Ando

Studies on novel HIF activators, A-503451sII: biological activities of A-503451A March 9 2016. doi:10.1038/ja.2016.20 Hideki Kobayashi, Takao Ohyama, Michiko Kitamura-Miyazaki, Yuki Hirota-Takahata & Osamu Ando

Inhibition of protein SUMOylation by natural quinones March 9 2016. doi:10.1038/ja.2016.23 Isao Fukuda, Mikako Hirohama, Akihiro Ito, Mohammad Tariq, Yasuhiro Igarashi, Hisato Saitoh & Minoru Yoshida

Pairwise antibiotic interactions in Escherichia coli: triclosan, rifampicin and aztreonam with nine other classes of antibiotics March 9 2016. doi:10.1038/ja.2016.26 Caroline Nguyen, Alice Zhou, Ayesha Khan, Jeffrey H Miller & Pamela Yeh

Hangtaimycin, a peptide secondary metabolite discovered from Streptomyces spectabilis CPCC 200148 by chemical screening March 9 2016. doi:10.1038/ja.2016.29 Lijie Zuo, Bingya Jiang, Zhibo Jiang, Wei Zhao, Shufen Li, Hongyu Liu, Bin Hong, Liyan Yu, Limin Zuo & Linzhuan Wu

Biosynthesis of the α-nitro-containing cyclic tripeptide psychrophilin March 9 2016. doi:10.1038/ja.2016.33 Muxun Zhao, Hsiao-Ching Lin & Yi Tang

In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumoniae March 2 2016. doi:10.1038/ja.2016.15 Xiao-Yuan Zhou, Xiao-Guang Ye, Li-Ting He, Su-Rong Zhang, Ruo-Lun Wang, Jun Zhou & Zhuo-Shan He

Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides February 24 2016. doi:10.1038/ja.2016.11 Yang Liu, Tibor Kurtán, Chang Yun Wang, Wen Han Lin, Raha Orfali, Werner EG Müller, Georgios Daletos & Peter Proksch

Albaflavenoid, a new tricyclic sesquiterpenoid from Streptomyces violascens February 24 2016. doi:10.1038/ja.2016.12 Dan Zheng, Nan Ding, Yi Jiang, Jiaoyue Zhang, Jian Ma, Xiu Chen, Jiang Liu, Li Han & Xueshi Huang

Precursor-directed biosynthesis of new sansanmycin analogs bearing para-substituted-phenylalanines with high yields February 24 2016. doi:10.1038/ja.2016.2 Ningning Zhang, Li Liu, Guangzhi Shan, Qiang Cai, Xuan Lei, Bin Hong, Linzhuan Wu, Yunying Xie & Ruxian Chen

Effect of different agents with potential antibiofilm activity on antimicrobial susceptibility of biofilms formed by Staphylococcus spp. isolated from implant-related infections February 24 2016. doi:10.1038/ja.2016.9 Diana Molina-Manso, Gema Del-Prado, Enrique Gómez-Barrena, Jose Cordero-Ampuero, Ricardo Fernandez-Roblas & Jaime Esteban

Genome-based survey of nonribosomal peptide synthetase and polyketide synthase gene clusters in type strains of the genus Microtetraspora February 17 2016. doi:10.1038/ja.2015.139 Hisayuki Komaki, Natsuko Ichikawa, Tomohiko Tamura, Akio Oguchi, Moriyuki Hamada & Nobuyuki Fujita

Antimicrobial potency of single and combined mupirocin and monoterpenes, thymol, menthol and 1,8-cineole against Staphylococcus aureus planktonic and biofilm growth February 17 2016. doi:10.1038/ja.2016.10 Domagoj Kifer, Vedran Mužinić & Maja Šegvić Klarić

Hetiamacin B–D, new members of amicoumacin group antibiotics isolated from Bacillus subtilis PJS February 3 2016. doi:10.1038/ja.2016.3 Shaowei Liu, Xiaoyan Han, Zhongke Jiang, Gang Wu, Xinxin Hu, Xuefu You, Jiandong Jiang, Yubin Zhang & Chenghang Sun

Enantioselective total synthesis of naturally occurring eushearilide and evaluation of its antifungal activity January 27 2016. doi:10.1038/ja.2015.146 Takayuki Tonoi, Ryo Kawahara, Takehiko Inohana & Isamu Shiina

Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms January 27 2016. doi:10.1038/ja.2015.147 Yuuki Yamada, Mamoru Komatsu & Haruo Ikeda

Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action January 20 2016. doi:10.1038/ja.2015.145 Chinwe U Chukwudi & Liam Good

Distribution of PASTA domains in penicillin-binding proteins and serine/threonine kinases of Actinobacteria January 13 2016. doi:10.1038/ja.2015.138 Hiroshi Ogawara

Euvesperins A and B, new circumventors of arbekacin resistance in MRSA, produced by Metarhizium sp. FKI-7236 January 13 2016. doi:10.1038/ja.2015.140 Mayu Shiina, Takuya Suga, Yukihiro Asami, Kenichi Nonaka, Masato Iwatsuki, Satoshi Omura & Kazuro Shiomi

Aureosurfactin and 3-deoxyaureosurfactin, novel biosurfactants produced by Aureobasidium pullulans L3-GPY January 13 2016. doi:10.1038/ja.2015.141 Jong-Shik Kim, In-Kyoung Lee, Dae-Won Kim & Bong-Sik Yun

Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601 January 13 2016. doi:10.1038/ja.2015.142 Takuji Nakashima, Rei Miyano, Masato Iwatsuki, Tatsuya Shirahata, Toru Kimura, Yukihiro Asami, Yoshinori Kobayashi, Kazuro Shiomi, George A Petersson, Yōko Takahashi & Satoshi Ōmura

AN483, a new anti-MRSA compound from Streptomyces sp. January 13 2016. doi:10.1038/ja.2015.143 Yun J Kwon, Mi-Jin Sohn, Hiroyuki Koshino, Chang-Jin Kim & Won-Gon Kim

JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77 January 6 2016. doi:10.1038/ja.2015.135 Keiichiro Motohashi, Miho Izumikawa, Noritaka Kagaya, Motoki Takagi & Kazuo Shin-ya

Oxysporizoline, an antibacterial polycyclic quinazoline alkaloid from the marine-mudflat-derived fungus Fusarium oxysporum January 6 2016. doi:10.1038/ja.2015.137 Viviane Nenkep, Keumja Yun & Byeng Wha Son

Related Links
FramePlot 2.3 - protein-coding region prediction tool
2ndFind - secondary metabolite biosynthetic gene discovery tool
Codon Usage Table of The Genus Streptomyces (GenBank R.118)
Genome:
Streptomyces griseus IFO 13350
Streptomyces avermitilis MA-4680
Streptomyces coelicolor A3(2)
Saccharopolyspora erythraea NRRL 2338
Mycobacterium tuberculosis H37Rv
Corynebacterium diphtheriae
Corynebacterium efficiens YS-314
Noardia farcinica IFM 10152
Rhodococcus erythropolis PR4
Rhodococcus opacus B4
Rhodococcus jostii RHA1
Frankia spp.
National BioResource Project (NBRP)
Journal of Antibiotics
Novel Antibiotics DataBase [Download] [Search]
NCBI Taxonomy