Society for Actinomycetes Japan The
Society for
Actinomycetes
Japan



Established in 1955 and recognized in 1985 by the Science Council of Japan.
[Japanese Page]
[ISBA18] 18th International Symposium on the Biology of Actinomycetes
Jeju island, Korea during 23-27 May 2017
Early Bird Registration: Jul. 1st - Dec. 31st, 2016
2016 Annual Meeting of SAJ (Sep. 8-9, Tokyo)

Outline of SAJ

Newsletter
(Actinomycetologica)

Official Journal

JA Free Access (members only)

Digital Atlas of Actinomycetes Ver. 2

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http://www.actino.jp/.
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Topics
[2016/07/06] Newsletter Actinomycetologica 30(1) is out.
[2016/06/17] The ISBA18 webpage is now live on the internet.
[2016/05/25] [GIM2016] Abstruct submission: 1 June 2016
[2015/12/25] Official newsletter Actinomycetologica Vol.29 No.2 is out.
[2015/10/7] Professor Satoshi Omura, an honorary member of the SAJ, was awarded the 2015 Nobel Prize in Physiology or Medicine.
Natural Product Discovery & Development in The Post Genomic Era (San Diego, Jan. 11-14, 2015)
ISBA'17 (Kusadasi, Turkey, Oct. 8-12, 2014)
ESF-EMBO symposium on the Synthetic Biology of Antibiotic Production II (Spain, 8/30-9/4 2014)
JA's AOP web feed

Nature nurtures the design of new semi-synthetic macrolide antibiotics November 30 2016. doi:10.1038/ja.2016.137 Prabhavathi Fernandes, Evan Martens & David Pereira

Bacterial proteases, untapped antimicrobial drug targets November 30 2016. doi:10.1038/ja.2016.138 Elizabeth Culp & Gerard D Wright

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of MSD-819 (6-chloro-2-quinoxalinecarboxylic acid 1,4-dioxide) November 30 2016. doi:10.1038/ja.2016.140 Nicola Ooi & Alex J O'Neill

Quinoline and naphthalene derivatives from Saccharopolyspora sp. YIM M13568 November 30 2016. doi:10.1038/ja.2016.142 Mingwei Sun, Jinhuan Ou, Wenjun Li & Chunhua Lu

8′-epimer of herbicidin F and its congeners from Streptomyces sp. YIM 66142 November 23 2016. doi:10.1038/ja.2016.133 Ju-Cheng Zhang, Ya-Bin Yang, Guang-Yi Chen, Xiao-Zhan Li, Ming Hu, Bang-Yan Wang, Bao-Hui Ruan, Hao Zhou, Li-Xing Zhao & Zhong-Tao Ding

Anti-fungal activity of Ctn[15–34], the C-terminal peptide fragment of crotalicidin, a rattlesnake venom gland cathelicidin November 23 2016. doi:10.1038/ja.2016.135 Carolina Sidrim P Cavalcante, Cláudio B Falcão, Raquel OS Fontenelle, David Andreu & Gandhi Rádis-Baptista

Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges November 16 2016. doi:10.1038/ja.2016.136 Satoshi Yuzawa, Jay D Keasling & Leonard Katz

Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi November 9 2016. doi:10.1038/ja.2016.131 Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, R Edward Watts, Kwang-Min Kim, Mansi B Parekh, Abhijit Achyut Gurjarpadhye, David Solow-Cordero, Lobat Tayebi & Jayakumar Rajadas

A new cytotoxic and anti-fungal C-glycosylated benz[α]anthraquinone from the broth of endophytic Streptomyces blastomycetica strain F4-20 November 2 2016. doi:10.1038/ja.2016.126 He Yan, Yang Li, Xing Y Zhang, Wan Y Zhou & Tao J Feng

Re-identification of the ascofuranone-producing fungus Ascochyta viciae as Acremonium sclerotigenum November 2 2016. doi:10.1038/ja.2016.132 Yasuaki Hijikawa, Motomichi Matsuzaki, Shigeo Suzuki, Daniel Ken Inaoka, Ryoko Tatsumi, Yasutoshi Kido & Kiyoshi Kita

Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60 October 26 2016. doi:10.1038/ja.2016.130 Jiansong Li, Shaoyong Zhang, Hui Zhang, Haiyan Wang, Ji Zhang, Anliang Chen, Jidong Wang & Wensheng Xiang

Validation of the mutant selection window hypothesis with fosfomycin against Escherichia coli and Pseudomonas aeruginosa: an in vitro and in vivo comparative study October 19 2016. doi:10.1038/ja.2016.124 Ai-jun Pan, Qing Mei, Ying Ye, Hong-ru Li, Bao Liu & Jia-bin Li

Microbacterium lacusdiani sp. nov., a phosphate-solubilizing novel actinobacterium isolated from mucilaginous sheath of Microcystis October 19 2016. doi:10.1038/ja.2016.125 Bing-Huo Zhang, Nimaichand Salam, Juan Cheng, Han-Quan Li, Jian-Yuan Yang, Dai-Ming Zha, Qi-Gen Guo & Wen-Jun Li

Antibiotics in microbial coculture October 19 2016. doi:10.1038/ja.2016.127 Kenji Ueda & Teruhiko Beppu

Antiviral effect of theaflavins against caliciviruses October 19 2016. doi:10.1038/ja.2016.128 Mai Ohba, Tomoichiro Oka, Takayuki Ando, Saori Arahata, Asaka Ikegaya, Hirotaka Takagi, Naohisa Ogo, Chelsea Zhu, Kazuhiro Owada, Fumihiko Kawamori, Qiuhong Wang, Linda J Saif & Akira Asai

Amide compound synthesis by adenylation domain of bacillibactin synthetase October 12 2016. doi:10.1038/ja.2016.117 Tomoko Abe, Yoshiteru Hashimoto, Sayaka Sugimoto, Kenta Kobayashi, Takuto Kumano & Michihiko Kobayashi

Julian Davies and the discovery of kanamycin resistance transposon Tn5 October 12 2016. doi:10.1038/ja.2016.120 Douglas E Berg

Production of valuable compounds by molds and yeasts October 12 2016. doi:10.1038/ja.2016.121 Arnold L Demain & Evan Martens

New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883 October 12 2016. doi:10.1038/ja.2016.122 Zhikai Guo, Guohui Pan, Zhengren Xu, Dong Yang, Hindra, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan & Ben Shen

Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus October 12 2016. doi:10.1038/ja.2016.123 Irene Saugar, Brian Molloy, Eloisa Sanz, María Blanca Sánchez, María Fernández-Lobato & Antonio Jiménez

Synthesis and structure–activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs October 5 2016. doi:10.1038/ja.2016.114 Yoshinari Wakiyama, Ko Kumura, Eijiro Umemura, Satomi Masaki, Kazutaka Ueda, Yasuo Sato, Takashi Watanabe, Yoko Hirai & Keiichi Ajito

Three structurally-related impurities in norvancomycin drug substance October 5 2016. doi:10.1038/ja.2016.115 Zhibo Jiang, Xuan Lei, Minghua Chen, Bingya Jiang, Linzhuan Wu, Xuexia Zhang, Zhihui Zheng, Xinxin Hu, Xuefu You, Shuyi Si, Lifei Wang & Bin Hong

Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740 September 14 2016. doi:10.1038/ja.2016.116 Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Noriaki Sakata, Toshio Tsuchida & Kazuo Shin-ya

ASP2397: a novel antifungal agent produced by Acremonium persicinum MF-347833 September 7 2016. doi:10.1038/ja.2016.107 Ikuko Nakamura, Seiji Yoshimura, Teruhisa Masaki, Shigehiro Takase, Keisuke Ohsumi, Michizane Hashimoto, Shigetada Furukawa & Akihiko Fujie

Isolation of a new antibacterial peptide achromosin from Streptomyces achromogenes subsp. achromogenes based on genome mining September 7 2016. doi:10.1038/ja.2016.108 Issara Kaweewan, Mayumi Ohnishi-Kameyama & Shinya Kodani

Diapolic acid A–B from an endophytic fungus, Diaporthe terebinthifolii depicting antimicrobial and cytotoxic activity September 7 2016. doi:10.1038/ja.2016.109 Nalli Yedukondalu, Palak Arora, Bhumika Wadhwa, Fayaz Ahmad Malik, Ram A Vishwakarma, Vivek K Gupta, Syed Riyaz-Ul-Hassan & Asif Ali

Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3′-deoxygenation of aminoglycoside antibiotics September 7 2016. doi:10.1038/ja.2016.110 Fumitaka Kudo, Takahiro Tokumitsu & Tadashi Eguchi

A new polysubstituted cyclopentene derivative from Streptomyces sp. HS-NF-1046 September 7 2016. doi:10.1038/ja.2016.111 Mei-yue Gao, Huan Qi, Jian-song Li, Hui Zhang, Ji Zhang, Ji-dong Wang & Wen-sheng Xiang

A new cyano-substituted anthracycline metabolite from Streptomyces sp. HS-NF-1006 September 7 2016. doi:10.1038/ja.2016.112 Xu Wan, Hui-jun Ren, Min-na Du, Huan Qi, Hui Zhang, An-liang Chen & Ji-dong Wang

Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355 September 7 2016. doi:10.1038/ja.2016.113 Toshihiko Nogawa, Akiko Okano, Chung Liang Lim, Yushi Futamura, Takeshi Shimizu, Shunji Takahashi, Darah Ibrahim & Hiroyuki Osada

Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection August 31 2016. doi:10.1038/ja.2016.106 Ikuko Nakamura, Ryuichi Kanasaki, Koji Yoshikawa, Shigetada Furukawa, Akihiko Fujie, Hiroshi Hamamoto & Kazuhisa Sekimizu

In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-5 August 24 2016. doi:10.1038/ja.2016.102 Suresh Panthee, Hiroshi Hamamoto, Yutaka Suzuki & Kazuhisa Sekimizu

Activity of tick antimicrobial peptide from Ixodes persulcatus (persulcatusin) against cell membranes of drug-resistant Staphylococcus aureus August 17 2016. doi:10.1038/ja.2016.101 Naruhide Miyoshi, Emiko Isogai, Keiichi Hiramatsu & Takashi Sasaki

Vestaines, novel vasoactive compounds, isolated from Streptomyces sp. SANK 63697 August 17 2016. doi:10.1038/ja.2016.98 Yuki Hirota-Takahata, Emi Kurosawa, Yoko Ishimoto, Yuko Iwadate, Masaaki Kizuka, Jun Chiba, Toru Hasegawa, Masahiro Tanaka & Hideki Kobayashi

Germicidins H–J from Streptomyces sp. CB00361 August 10 2016. doi:10.1038/ja.2016.100 Ming Ma, Mostafa E Rateb, Dong Yang, Jeffrey D Rudolf, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan & Ben Shen

CD101, a novel echinocandin with exceptional stability properties and enhanced aqueous solubility August 10 2016. doi:10.1038/ja.2016.89 B Radha Krishnan, Kenneth D James, Karen Polowy, B J Bryant, Anu Vaidya, Steve Smith & Christopher P Laudeman

Allantopyrone A activates Keap1–Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death August 10 2016. doi:10.1038/ja.2016.99 Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Yoshihito Shiono, Hiroyuki Osada & Ken-ichi Kimura

New aliphatic acid amides from Streptomyces maoxianensis sp. nov. July 27 2016. doi:10.1038/ja.2016.90 Jin-Meng Li, Kai Yan, Hui Zhang, Huan Qi, Ji Zhang, Wen-Sheng Xiang, Ji-Dong Wang & Xiang-Jing Wang

In vitro activity of tigecycline in combination with rifampin, doripenem or ceftazidime against carbapenem-resistant Klebsiella pneumoniae bloodstream isolates July 27 2016. doi:10.1038/ja.2016.93 Yongbo Zhang, Peizhen Li, Yuhan Yin, Fuqiang Li & Qinghua Zhang

Identification of a prodigiosin cyclization gene in the roseophilin producer and production of a new cyclized prodigiosin in a heterologous host July 27 2016. doi:10.1038/ja.2016.94 Shoko Kimata, Masumi Izawa, Takashi Kawasaki & Yoichi Hayakawa

Versicones E–H and arugosin K produced by the mangrove-derived fungus Aspergillus versicolor HDN11-84 July 27 2016. doi:10.1038/ja.2016.95 Feng Li, Wenqiang Guo, Qian Che, Tianjiao Zhu, Qianqun Gu & Dehai Li

New tenvermectin analogs obtained by microbial conversion with Saccharopolyspora erythraea July 20 2016. doi:10.1038/ja.2016.91 Xu Wan, Shao-yong Zhang, Hui Zhang, Jun Zhai, Jun Huang, An-liang Chen & Ji-dong Wang

Polyols, not sugars, determine the structural diversity of anti-streptococcal liamocins produced by Aureobasidium pullulans strain NRRL 50380 July 20 2016. doi:10.1038/ja.2016.92 Neil PJ Price, Kenneth M Bischoff, Timothy D Leathers, Allard A Cossé & Pennapa Manitchotpisit

Antibiotic combinations for controlling colistin-resistant Enterobacter cloacae July 6 2016. doi:10.1038/ja.2016.77 Thais Bergamin Lima, Osmar Nascimento Silva, Keyla Caroline de Almeida, Suzana Meira Ribeiro, Dielle de Oliveira Motta, Simone Maria-Neto, Michelle Brizolla Lara, Carlos Roberto Souza Filho, Alicia Simalie Ombredane, Celio de Faria Junior, Nadia Skorupa Parachin, Beatriz Simas Magalhães & Octávio Luiz Franco

Identification and biological activity of ogipeptins, novel LPS inhibitors produced by marine bacterium July 6 2016. doi:10.1038/ja.2016.81 Shiho Kozuma, Yuki Hirota-Takahata, Daisuke Fukuda, Nahoki Kuraya, Mutsuo Nakajima & Osamu Ando

Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects July 6 2016. doi:10.1038/ja.2016.82 Kozo Ochi

Antibiotics in the clinical pipeline at the end of 2015 June 29 2016. doi:10.1038/ja.2016.72 Mark S Butler, Mark AT Blaskovich & Matthew A Cooper

Antibacterial fatty acids destabilize hydrophobic and multicellular aggregates of biofilm in S. aureus June 29 2016. doi:10.1038/ja.2016.76 Zulfiqar Ali Mirani, Shagufta Naz, Fouzia Khan, Mubashir Aziz, Asadullah, Muhammad Naseem Khan & Seema Ismat Khan

Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil June 29 2016. doi:10.1038/ja.2016.78 Dominik Wichner, Hamidah Idris, Wael E Houssen, Andrew R McEwan, Alan T Bull, Juan A Asenjo, Michael Goodfellow, Marcel Jaspars, Rainer Ebel & Mostafa E Rateb

Synthesis and biological evaluation of lipophilic teicoplanin pseudoaglycon derivatives containing a substituted triazole function June 29 2016. doi:10.1038/ja.2016.80 Zsolt Szűcs, Magdolna Csávás, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Florent Perret, Eszter Ostorházi, Réka Szatmári, Evelien Vanderlinden, Lieve Naesens & Pál Herczegh

Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1 June 22 2016. doi:10.1038/ja.2016.60 Sifan Wu, Tingting Huang, Dan Xie, Jing Wo, Xiaozheng Wang, Zixin Deng & Shuangjun Lin

Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation June 22 2016. doi:10.1038/ja.2016.61 Yuki Hirota-Takahata, Shiho Kozuma, Nahoki Kuraya, Daisuke Fukuda, Mutsuo Nakajima, Toshio Takatsu & Osamu Ando

Metacycloprodigiosin induced cell death selectively in β-catenin-mutated tumor cells June 22 2016. doi:10.1038/ja.2016.75 Hiroaki Ikeda, Yuki Shikata, Ramida Watanapokasin, Etsu Tashiro & Masaya Imoto

Surfactin derivatives from Micromonospora sp. CPCC 202787 and their anti-HIV activities June 15 2016. doi:10.1038/ja.2016.63 Xu Pang, Jianyuan Zhao, Xiaomei Fang, Hongyu Liu, Yuqin Zhang, Shan Cen & Liyan Yu

Impact of Staphylococcus aureus accessory gene regulator (agr) system on linezolid efficacy by profiling pharmacodynamics and RNAIII expression June 8 2016. doi:10.1038/ja.2016.59 Rachel L Soon, Justin R Lenhard, Irene Reilly, Tanya Brown, Alan Forrest & Brian T Tsuji

RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441 June 8 2016. doi:10.1038/ja.2016.65 Jun-Pil Jang, Shunji Takahashi, Yushi Futamura, Toshihiko Nogawa, Jae-Hyuk Jang, Jong Seog Ahn & Hiroyuki Osada

Eighth Korea–Japan Chemical Biology symposium: chemical biology notes from a small island June 1 2016. doi:10.1038/ja.2016.58 Tilman Schneider-Poetsch, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn & Hiroyuki Osada

Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus May 25 2016. doi:10.1038/ja.2016.62 Joao C S Cruz, Sonia I Maffioli, Alice Bernasconi, Cristina Brunati, Eleonora Gaspari, Margherita Sosio, Elizabeth Wellington & Stefano Donadio

Efficacy of ampicillin against methicillin-resistant Staphylococcus aureus restored through synergy with branched poly(ethylenimine) May 18 2016. doi:10.1038/ja.2016.44 Melissa A Foxley, Anthony W Friedline, Jessica M Jensen, Susan L Nimmo, Erin M Scull, Jarrod B King, Stoffel Strange, Min T Xiao, Benjamin E Smith, Kieth J Thomas III, Daniel T Glatzhofer, Robert H Cichewicz & Charles V Rice

Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis May 18 2016. doi:10.1038/ja.2016.45 Shasha Rao, Clive A Prestidge, Lynn Miesel, Deb Sweeney, Dean L Shinabarger & Ramiz A Boulos

Antibacterial activity of the novel semisynthetic lantibiotic NVB333 in vitro and in experimental infection models May 18 2016. doi:10.1038/ja.2016.47 Steven Boakes, William J Weiss, Mary Vinson, Sjoerd Wadman & Michael J Dawson

Design, synthesis and microbiological evaluation of ampicillin–tetramic acid hybrid antibiotics May 18 2016. doi:10.1038/ja.2016.52 Philip T Cherian, Aditi Deshpande, Martin N Cheramie, David F Bruhn, Julian G Hurdle & Richard E Lee

DNA sequence-selective C8-linked pyrrolobenzodiazepine–heterocyclic polyamide conjugates show anti-tubercular-specific activities May 11 2016. doi:10.1038/ja.2016.43 Federico Brucoli, Juan D Guzman, Mohammad A Basher, Dimitrios Evangelopoulos, Eleanor McMahon, Tulika Munshi, Timothy D McHugh, Keith R Fox & Sanjib Bhakta

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209 May 11 2016. doi:10.1038/ja.2016.46 Aika Suzuki, Takashi Fukuda, Keisuke Kobayashi, Taichi Ohshiro & Hiroshi Tomoda

Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation May 11 2016. doi:10.1038/ja.2016.48 Aysegul Saral, David A Leonard, Azer Ozad Duzgun, Aysegul Copur Cicek, Cynthia M June & Cemal Sandalli

Quantitative measurement of the outer membrane permeability in Escherichia coli lpp and tol–pal mutants defines the significance of Tol–Pal function for maintaining drug resistance May 11 2016. doi:10.1038/ja.2016.50 Hikaru Kowata, Saeko Tochigi, Tomonobu Kusano & Seiji Kojima

Related Links
FramePlot 2.3 - protein-coding region prediction tool
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Codon Usage Table of The Genus Streptomyces (GenBank R.118)
Genome:
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NCBI Taxonomy