Society for Actinomycetes Japan The
Society for
Actinomycetes
Japan



Established in 1955 and recognized in 1985 by the Science Council of Japan.
[Japanese Page]
[ISBA18] 18th International Symposium on the Biology of Actinomycetes
Jeju island, Korea during 23-27 May 2017
Abstract Oral, Feb. 22nd, 2017; Poster, Apr. 15th, 2017.
2016 Annual Meeting of SAJ (Sep. 8-9, Tokyo)

Outline of SAJ

Newsletter
(Actinomycetologica)

Official Journal

JA Free Access (members only)

Digital Atlas of Actinomycetes Ver. 2

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Topics
[2017/01/17] Newsletter Actinomycetologica 30(2) is out.
[2016/07/06] Newsletter Actinomycetologica 30(1) is out.
[2016/06/17] The ISBA18 webpage is now live on the internet.
[2016/05/25] [GIM2016] Abstract submission: 1 June 2016
[2015/12/25] Official newsletter Actinomycetologica Vol.29 No.2 is out.
[2015/10/7] Professor Satoshi Omura, an honorary member of the SAJ, was awarded the 2015 Nobel Prize in Physiology or Medicine.
Natural Product Discovery & Development in The Post Genomic Era (San Diego, Jan. 11-14, 2015)
ISBA'17 (Kusadasi, Turkey, Oct. 8-12, 2014)
ESF-EMBO symposium on the Synthetic Biology of Antibiotic Production II (Spain, 8/30-9/4 2014)
JA's AOP web feed

The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains February 15 2017. doi:10.1038/ja.2017.10 Natalie Gugala, Joe A Lemire & Raymond J Turner

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations February 15 2017. doi:10.1038/ja.2017.11 Andy Crump

Biosynthetic studies on terpenoids produced by Streptomyces February 15 2017. doi:10.1038/ja.2017.12 Tomohisa Kuzuyama

Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D February 15 2017. doi:10.1038/ja.2017.13 Dong Yang, Mostafa E Rateb, Nan Wang & Ben Shen

Acremopeptin, a new peptaibol from Acremonium sp. PF1450 February 15 2017. doi:10.1038/ja.2017.15 Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa, Yumiko Kubota, Takao Kunisada, Isao Momose, Manabu Kawada & Masakatsu Shibasaki

Two new polyketides from the ascomycete fungus Leptosphaeria sp. February 15 2017. doi:10.1038/ja.2017.5 Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Erwei Li & Ling Liu

Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus February 15 2017. doi:10.1038/ja.2017.7 Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya & Kazuhisa Sekimizu

Genus Kitasatospora, taxonomic features and diversity of secondary metabolites February 15 2017. doi:10.1038/ja.2017.8 Yōko Takahashi

Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2 February 15 2017. doi:10.1038/ja.2017.9 Isao Momose & Takumi Watanabe

Streptomyces euryhalinus sp. nov., a new actinomycete isolated from a mangrove forest February 8 2017. doi:10.1038/ja.2017.3 Kaushik Biswas, Jayanta D Choudhury, Riddhi Mahansaria, Malay Saha & Joydeep Mukherjee

Antarlides F–H, new members of the antarlide family produced by Streptomyces sp. BB47 February 8 2017. doi:10.1038/ja.2017.6 Shun Saito, Takahiro Fujimaki, Watanalai Panbangred, Ryuichi Sawa, Yasuhiro Igarashi & Masaya Imoto

Lipophilic teicoplanin pseudoaglycon derivatives are active against vancomycin- and teicoplanin-resistant enterococci February 1 2017. doi:10.1038/ja.2017.2 Zsolt Szűcs, Ilona Bereczki, Magdolna Csávás, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Eszter Ostorházi, Réka Szatmári & Pál Herczegh

Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample January 25 2017. doi:10.1038/ja.2016.169 Bin Yang, Huaming Tao, Xiao-Chu Qin, Zhen Wang, Junde Dong, Xiuping Lin, Xuefeng Zhou, Jian-Lin Li, Zheng-Chao Tu & Yonghong Liu

Molecular beacons to identify gifted microbes for genome mining January 25 2017. doi:10.1038/ja.2017.1 Richard H Baltz

The ups and downs of drug discovery: the early history of Fidaxomicin January 18 2017. doi:10.1038/ja.2016.157 James B McAlpine

Simamycin (5′-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp. January 18 2017. doi:10.1038/ja.2016.163 Yasuhiro Igarashi, Takayuki Kyoso, Youngju Kim & Tsutomu Oikawa

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae January 18 2017. doi:10.1038/ja.2016.164 Yoshihiro Watanabe, Takuya Suga, Satomi Narusawa, Masato Iwatsuki, Kenichi Nonaka, Takuji Nakashima, Yasuo Shinohara, Takahiro Shiotsuki, Naoya Ichimaru, Hideto Miyoshi, Yukihiro Asami, Satoshi Ōmura & Kazuro Shiomi

Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis January 18 2017. doi:10.1038/ja.2016.165 Sheo B Singh, Libo Xu, Peter T Meinke, Natalia Kurepina, Barry N Kreiswirth, David B Olsen & Katherine Young

The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues January 18 2017. doi:10.1038/ja.2016.166 Takamichi Imaizumi, Hiroshi Nakagawa, Ran Hori, Yasuo Watanabe, Shiro Soga, Kyoichiro Iida & Hideyuki Onodera

Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684 January 18 2017. doi:10.1038/ja.2016.167 Toshihiko Nogawa, Noriko Ogita, Yushi Futamura, Shigenori Negishi, Nobumoto Watanabe & Hiroyuki Osada

MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane January 18 2017. doi:10.1038/ja.2016.168 Yusuke Kanda, Youhei Yamasaki, Satomi Shimura, Shinji Kamisuki, Fumio Sugawara, Yoko Nagumo & Takeo Usui

Enhanced dereplication of fungal cultures via use of mass defect filtering January 11 2017. doi:10.1038/ja.2016.145 Noemi D Paguigan, Tamam El-Elimat, Diana Kao, Huzefa A Raja, Cedric J Pearce & Nicholas H Oberlies

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections January 11 2017. doi:10.1038/ja.2016.146 Pamela Brown & Michael J Dawson

Biphenyl ether derivatives with protein tyrosine phosphatase 1B inhibitory activity from the freshwater fungus Phoma sp. January 11 2017. doi:10.1038/ja.2016.147 Deiske A Sumilat, Hiroyuki Yamazaki, Syu-ichi Kanno, Ryo Saito, Yuta Watanabe & Michio Namikoshi

In vitro antibacterial activity of α-methoxyimino acylide derivatives against macrolide-resistant pathogens and mutation analysis in 23S rRNA January 11 2017. doi:10.1038/ja.2016.148 Hiroyuki Sugiyama, Ippei Yoshida, Mayumi Ueki, Katsuhiko Tanabe, Akira Manaka & Keiichi Hiramatsu

Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening January 11 2017. doi:10.1038/ja.2016.155 Ryo Horikoshi, Kimihiko Goto, Masaaki Mitomi, Kazuhiko Oyama, Toshiaki Sunazuka & Satoshi Ōmura

Effects of two 6-quinolinyl chalcones on the integrity of plasma membrane of Paracoccidioides brasiliensis January 11 2017. doi:10.1038/ja.2016.156 Nívea P de Sá, Patrícia S Cisalpino, Luciana C Tavares, Leandro Espíndola, Beatriz M Borelli, Paulo JS Barbeira, Gabriele de Matos Cardoso Perdigão, Elaine M Souza-Fagundes, Carlos A Rosa, Moacir G Pizzolatti & Susana Johann

Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490 January 11 2017. doi:10.1038/ja.2016.158 Yixizhuoma, Naoki Ishikawa, Mohamed S Abdelfattah & Masami Ishibashi

Anti-folates potentiate bactericidal effects of other antimicrobial agents January 11 2017. doi:10.1038/ja.2016.159 Kun Li, Xu-de Wang, Shan-shan Yang, Jing Gu, Jiao-yu Deng & Xian-En Zhang

Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale January 11 2017. doi:10.1038/ja.2016.160 Mei Liu, Pei Huang, Qian Wang, Biao Ren, Ayokunmi Oyeleye, Miaomiao Liu, Jingyu Zhang, Xiaolin Li, Xiaoping Zhang, Lixin Zhang & Xueting Liu

Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6 January 11 2017. doi:10.1038/ja.2016.161 Masayuki Igarashi, Ryuichi Sawa, Manabu Yamasaki, Chigusa Hayashi, Maya Umekita, Masaki Hatano, Toshinobu Fujiwara, Kiyohisa Mizumoto & Akio Nomoto

Arabilin overcomes resistance to AR-targeted therapy January 11 2017. doi:10.1038/ja.2016.162 Takahiro Fujimaki, Shun Saito & Masaya Imoto

Antimicrobial activity and interactions of cationic peptides derived from Galleria mellonella cecropin D-like peptide with model membranes December 21 2016. doi:10.1038/ja.2016.134 José Oñate-Garzón, Marcela Manrique-Moreno, Steven Trier, Chad Leidy, Rodrigo Torres & Edwin Patiño

Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library December 21 2016. doi:10.1038/ja.2016.143 Jae Kyoung Lee, Jae-Hyuk Jang, Dong-Jin Park, Chang-Jin Kim, Jong Seog Ahn, Bang Yeon Hwang & Young-Soo Hong

Studies at the ionizable position of cephalosporins and penicillins: hydroxamates as substitutes for the traditional carboxylate group December 21 2016. doi:10.1038/ja.2016.149 Mark W Majewski, Patricia A Miller & Marvin J Miller

In vitro and in vivo activities of the diazabicyclooctane OP0595 against AmpC-derepressed Pseudomonas aeruginosa December 21 2016. doi:10.1038/ja.2016.150 Akihiro Morinaka, Yuko Tsutsumi, Keiko Yamada, Yoshihiro Takayama, Shiro Sakakibara, Toshihiko Takata, Takao Abe, Takeshi Furuuchi, Seiichi Inamura, Yoshiaki Sakamaki, Nakako Tsujii & Takashi Ida

Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases December 21 2016. doi:10.1038/ja.2016.151 Yoko Eguchi, Toshihide Okajima, Naoya Tochio, Yoichi Inukai, Riko Shimizu, Shuhei Ueda, Shoko Shinya, Takanori Kigawa, Tamo Fukamizo, Masayuki Igarashi & Ryutaro Utsumi

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1 December 21 2016. doi:10.1038/ja.2016.152 Takashi Fukuda, Misaki Takahashi, Kenichiro Nagai, Enjuro Harunari, Chiaki Imada & Hiroshi Tomoda

Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506 December 21 2016. doi:10.1038/ja.2016.153 Shan Lu, Shinichi Nishimura, Masashi Ito, Taira Kato & Hideaki Kakeya

Antibacterial effect of antibiotic-loaded SBA-15 on biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis December 21 2016. doi:10.1038/ja.2016.154 Anna Aguilar-Colomer, Juan Carlos Doadrio, Concepción Pérez-Jorge, Miguel Manzano, Maria Vallet-Regí & Jaime Esteban

New aminoglycoside-modifying enzymes APH(3′)-VIII and APH(3′)-IX in Acinetobacter rudis and Acinetobacter gerneri December 14 2016. doi:10.1038/ja.2016.144 Eun-Jeong Yoon, Catherine Grillot-Courvalin & Patrice Courvalin

Synthesis and antibacterial activity of novel lincomycin derivatives. II. Exploring (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives December 7 2016. doi:10.1038/ja.2016.139 Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Takashi Watanabe, Megumi Kumura, Takuji Yoshida & Keiichi Ajito

Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance December 7 2016. doi:10.1038/ja.2016.141 Tomoyasu Hirose, Yasuhiro Kojima, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Kazuro Shiomi, Satoshi Ōmura & Toshiaki Sunazuka

Nature nurtures the design of new semi-synthetic macrolide antibiotics November 30 2016. doi:10.1038/ja.2016.137 Prabhavathi Fernandes, Evan Martens & David Pereira

Bacterial proteases, untapped antimicrobial drug targets November 30 2016. doi:10.1038/ja.2016.138 Elizabeth Culp & Gerard D Wright

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of MSD-819 (6-chloro-2-quinoxalinecarboxylic acid 1,4-dioxide) November 30 2016. doi:10.1038/ja.2016.140 Nicola Ooi & Alex J O'Neill

Quinoline and naphthalene derivatives from Saccharopolyspora sp. YIM M13568 November 30 2016. doi:10.1038/ja.2016.142 Mingwei Sun, Jinhuan Ou, Wenjun Li & Chunhua Lu

8′-epimer of herbicidin F and its congeners from Streptomyces sp. YIM 66142 November 23 2016. doi:10.1038/ja.2016.133 Ju-Cheng Zhang, Ya-Bin Yang, Guang-Yi Chen, Xiao-Zhan Li, Ming Hu, Bang-Yan Wang, Bao-Hui Ruan, Hao Zhou, Li-Xing Zhao & Zhong-Tao Ding

Anti-fungal activity of Ctn[15–34], the C-terminal peptide fragment of crotalicidin, a rattlesnake venom gland cathelicidin November 23 2016. doi:10.1038/ja.2016.135 Carolina Sidrim P Cavalcante, Cláudio B Falcão, Raquel OS Fontenelle, David Andreu & Gandhi Rádis-Baptista

Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges November 16 2016. doi:10.1038/ja.2016.136 Satoshi Yuzawa, Jay D Keasling & Leonard Katz

Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi November 9 2016. doi:10.1038/ja.2016.131 Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, R Edward Watts, Kwang-Min Kim, Mansi B Parekh, Abhijit Achyut Gurjarpadhye, David Solow-Cordero, Lobat Tayebi & Jayakumar Rajadas

A new cytotoxic and anti-fungal C-glycosylated benz[α]anthraquinone from the broth of endophytic Streptomyces blastomycetica strain F4-20 November 2 2016. doi:10.1038/ja.2016.126 He Yan, Yang Li, Xing Y Zhang, Wan Y Zhou & Tao J Feng

Re-identification of the ascofuranone-producing fungus Ascochyta viciae as Acremonium sclerotigenum November 2 2016. doi:10.1038/ja.2016.132 Yasuaki Hijikawa, Motomichi Matsuzaki, Shigeo Suzuki, Daniel Ken Inaoka, Ryoko Tatsumi, Yasutoshi Kido & Kiyoshi Kita

Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60 October 26 2016. doi:10.1038/ja.2016.130 Jiansong Li, Shaoyong Zhang, Hui Zhang, Haiyan Wang, Ji Zhang, Anliang Chen, Jidong Wang & Wensheng Xiang

Antibiotics in microbial coculture October 19 2016. doi:10.1038/ja.2016.127 Kenji Ueda & Teruhiko Beppu

Antiviral effect of theaflavins against caliciviruses October 19 2016. doi:10.1038/ja.2016.128 Mai Ohba, Tomoichiro Oka, Takayuki Ando, Saori Arahata, Asaka Ikegaya, Hirotaka Takagi, Naohisa Ogo, Chelsea Zhu, Kazuhiro Owada, Fumihiko Kawamori, Qiuhong Wang, Linda J Saif & Akira Asai

Amide compound synthesis by adenylation domain of bacillibactin synthetase October 12 2016. doi:10.1038/ja.2016.117 Tomoko Abe, Yoshiteru Hashimoto, Sayaka Sugimoto, Kenta Kobayashi, Takuto Kumano & Michihiko Kobayashi

Julian Davies and the discovery of kanamycin resistance transposon Tn5 October 12 2016. doi:10.1038/ja.2016.120 Douglas E Berg

Production of valuable compounds by molds and yeasts October 12 2016. doi:10.1038/ja.2016.121 Arnold L Demain & Evan Martens

New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883 October 12 2016. doi:10.1038/ja.2016.122 Zhikai Guo, Guohui Pan, Zhengren Xu, Dong Yang, Hindra, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan & Ben Shen

Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus October 12 2016. doi:10.1038/ja.2016.123 Irene Saugar, Brian Molloy, Eloisa Sanz, María Blanca Sánchez, María Fernández-Lobato & Antonio Jiménez

Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3′-deoxygenation of aminoglycoside antibiotics September 7 2016. doi:10.1038/ja.2016.110 Fumitaka Kudo, Takahiro Tokumitsu & Tadashi Eguchi

Allantopyrone A activates Keap1–Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death August 10 2016. doi:10.1038/ja.2016.99 Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Yoshihito Shiono, Hiroyuki Osada & Ken-ichi Kimura

Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil June 29 2016. doi:10.1038/ja.2016.78 Dominik Wichner, Hamidah Idris, Wael E Houssen, Andrew R McEwan, Alan T Bull, Juan A Asenjo, Michael Goodfellow, Marcel Jaspars, Rainer Ebel & Mostafa E Rateb

Related Links
FramePlot 2.3 - protein-coding region prediction tool
2ndFind - secondary metabolite biosynthetic gene discovery tool
Codon Usage Table of The Genus Streptomyces (GenBank R.118)
Genome:
Streptomyces griseus IFO 13350
Streptomyces avermitilis MA-4680
Streptomyces coelicolor A3(2)
Saccharopolyspora erythraea NRRL 2338
Mycobacterium tuberculosis H37Rv
Corynebacterium diphtheriae
Corynebacterium efficiens YS-314
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National BioResource Project (NBRP)
Journal of Antibiotics
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NCBI Taxonomy